Fig. 4

Nociceptive behavior and CBS, TRPA1, TRPC6 and TRPV1 protein expression of the dorsal root ganglia obtained from normoglycemic and diabetic rats at 21 days post-streptozotocin injection. a Protein expression of CBS (control) or CBS + control peptide (Pep) in normoglycemic rats. b Nociceptive behavior and c CBS protein expression obtained in normoglycemic rats (NG) and diabetic rats (D) submitted to subcutaneous administration of vehicle (Veh), NaHS (100 μg/paw) or hydroxylamine (HA; 0.1 μg/paw) during 21 days. d TRPA1 protein expression in normoglycemic and diabetic rats 21 days after streptozotocin injection. e TRPC6 channel protein expression observed in normoglycemic rats (NG) and diabetic rats treated with vehicle (Veh), NaHS (100 μg/paw), hydroxylamine (HA; 0.1 μg/paw), SKF-96365 (SKF; 100 μg/paw, s.c.) or SKF + NaHS (100 μg/paw + 100 μg/paw, respectively) during 21 days. f TRPV1 protein expression in normoglycemic and diabetic rats 21 days after streptozotocin injection. Data were normalized against β-actin and are expressed as the mean ± SEM of 5–6 animals. *Significantly different from control or normoglycemic (NG) group, ^#significantly different from vehicle (Veh, diabetic rats) group and ^&significantly different from SKF-96365 (SKF) group (P < 0.05) determined by one-way ANOVA followed by the Student–Newman–Keuls’ test