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Fig. 4 | BMC Neuroscience

Fig. 4

From: Dyskinesia and brain-derived neurotrophic factor levels after long-term levodopa and nicotinic receptor agonist treatments in female mice with near-total unilateral dopaminergic denervation

Fig. 4

Brain-derived neurotrophic factor (BDNF) protein levels in chronically drug-treated lesioned mice. a No interhemispheric differences in BDNF protein levels of the striatum and the prefrontal cortex were found after 15 weeks of levodopa treatment. After 10 weeks of chronic nicotine treatment BDNF levels were reduced in the prefrontal cortex of nicotine-treated animals, with no effect on striatal BDNF. Plots show median, quartiles, range, and distribution (n = 6 per group). **Main effect of treatment P < 0.01, two-way ANOVA. b BDNF levels in the lesioned striatum were positively correlated with dyskinesia severity (r = 0.582, P < 0.05, n = 12)

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BMC Neuroscience

ISSN: 1471-2202

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