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Fig. 2 | BMC Neuroscience

Fig. 2

From: Dyskinesia and brain-derived neurotrophic factor levels after long-term levodopa and nicotinic receptor agonist treatments in female mice with near-total unilateral dopaminergic denervation

Fig. 2

Characterization of the near-total unilateral nigrostriatal lesion model. a Representative section, immunostained for tyrosine hydroxylase, showing the ventral midbrain dopaminergic areas, including the substantia nigra pars compacta (SNC), of a study animal lesioned with a 6-hydroxydopamine injection into the medial forebrain bundle. b Tyrosine hydroxylase (TH)-positive immunostaining remaining in the SNC of the study animals at the end of the experiments (n = 10). Less immunostaining remained in animals treated chronically with nicotine. c Dopamine remaining in the dorsal striatum of a separate set of animals, lesioned with identical 6-hydroxydopamine injections, as measured with HPLC (n =5). *Difference to vehicle, P < 0.05, t test

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BMC Neuroscience

ISSN: 1471-2202

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