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Fig. 8 | BMC Neuroscience

Fig. 8

From: Biaryl scaffold-focused virtual screening for anti-aggregatory and neuroprotective effects in Alzheimer’s disease

Fig. 8

The boiled egg model to graphically represent the intestinal absorption and the brain penetration of the ligands as function of lipophilicity and polar surface area of the molecules. The molecules (represented as dots) within the yellow yolk are well penetrated within the brain with good intestinal absorption. The molecules represented with blue dots could be a substrate for P-Glycoprotein, reducing their absorption and penetration within brain

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