Fig. 3
PA28αOE mice exhibit improved learning/memory. a Activity box measurements of exploratory behavior; locomotion, rearing and corner time in novel (day 1) and acquainted (day 2) environment. On day 2, PA28αOE females spent longer time in the corners (P = 0.034; two-way ANOVA repeated measurements, followed by Sidak test, F(1, 14) = 5498), and exhibited a strong tendency of reduced rearing [P = 0.065; F(1, 14) = 3992], both of which are indicators of more proficient habituation. Locomotion on day 2 between PA28αOE and WT is not statistically different (P = 0.19). Values are mean ± SEM. b Shuttle box passive avoidance test assesses learning and memory capability. On day 1 (Pday1= 0.194, Mantel–Cox survival test) a small electric shock was given to PA28αOE female mice and their wildtype female littermates upon voluntarily entering a dark compartment. As shown, on day 2 there is a significant difference between PA28αOE and WT in re-entering the compartment (Pday2= 0.0056). Maximum assay time was 300 s (i.e. no entry = 300 s). Dashed lines correspond to 95% confidence interval