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Fig. 1 | BMC Neuroscience

Fig. 1

From: Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs

Fig. 1

Schematic representation of the Dclk1 gene and psychotropic drug treatment-mediated regulation of its expression. a Main transcripts of the Dclk1 locus: two Cpg16 variants (ENSMUST00000198437, ENSMUST00000070418), Carp (ENSMUST00000199585), intron-retained isoform (RI, ENSMUST00000198757), Dcl (ENSMUST00000167204) and Dclk1 (ENSMUST00000054237). The positions of the microarray probes are indicated by the stars. The schematic was generated based on information in the Ensembl database and available literature [6, 26]. The functional protein domains are boxed (SP is the serine/proline-rich domain). b Results from the microarray gene expression analysis are presented as time courses (1, 2, 4 and 8 h) of fold changes in expression compared to levels observed in saline-treated controls (as described in the legend). The measurements from two microarray probes are presented. The left side of the figure shows Dclk1 levels based on the ILMN_1259689 probe, whereas the right side corresponds to ILMN_2434274. The list of analyzed drugs include mianserin (MIA), imipramine (IMI), fluoxetine (FLU), bupropion (BUP), tianeptine (TIA), tranylcypromine (TRA), methamphetamine (MET), cocaine (COC), nicotine (NIC), heroin (HER), morphine (MOR), ethanol (ETO), diazepam (DIA), buspirone (BUS), hydroxyzine (HYD), clozapine (CLO), risperidone (RIS), haloperidol (HAL), saline (SAL), and naive (NAI) control. *P < 0.01, **P < 0.001, ***P < 0.0001, one-way ANOVA of the drug factor

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