Skip to main content

Table 6 Comparison of k4 values (2 compartment model) between 18F-florbetabenand 18F-flutemetamol in AD transgenic group

From: Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer’s disease with PET imaging agents 18F-flutemetamol and 18F-florbetaben

Group

Rstr

Lstr

Cor

Rhip

Lhip

Thal

Crbl

18F-flutemetamol

 Mean + SD

2.281 ± 3.510

1.622 ± 2.793

2.950 ± 3.210

4.551 ± 3.982

2.432 ± 3.982

1.281 ± 3.982

2.403 ± 3.982

 Median (IQR)

0.331 (0.18–6.77)

0.561 (0.35–1.06)

1.752 (0.37–7.23)

7.460 (0.32–7.87)

0.340 (0.13–7.71)

0.273 (0.11–0.44)

0.374 (0–7.28)

18F-florbetaben

 Mean + SD

0.713 ± 1.010

1.327 ± 2.290

0.161 ± 0.150

0.321 ± 0.331

0.902 ± 1.880

2.190 ± 3.102

0.140 ± 0.141

 Median (IQR)

0.312 (0.22–0.92)

0.283 (0.25–2.03)

0.240 (0–0.29)

0.282 (0–0.41)

0.281 (0–0.35)

0.383 (0.21–6.15)

0.110 (0–0.3)

p-value

0.902

0.383

0.017**

0.053

0.383

0.535

0.165

  1. Cor cortex, Crbl cerebellum, Rhip Rt. hippocampus, Lhip Lt. hippocampus, Thala Thalamus, Rstr Rt. striatum, Lstr Lt. striatum, ** p < 0.05 considered as significant