Skip to main content

Advertisement

Fig. 4 | BMC Neuroscience

Fig. 4

From: Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis

Fig. 4

Behavioral flexibility in AppNL-G-F/NL-G-F and AppNL/NL mice assessed by spatial reversal leaning task using the Barnes maze. Behavioral flexibility was assessed at 4 (ac), 6 (df), and 8 (gi) months of age by spatial reversal learning task using the Barnes maze. At all ages, AppNL-G-F/NL-G-F and AppNL/NL mice performed equally well in acquisition of the new target hole in comparison with WT mice, as indicated by decreases in the number of errors (a, d, and g), latency (b, e, and h), and distance (c, f, and i) across the reversal sessions. At 6 months of age, AppNL/NL mice took more time to reach the new target hole only in the first session of the reversal phase (e). 4 month-old; n = 8 WT (B6J), n = 8 AppNL/NL, n = 7 AppNL-G-F/NL-G-F. 6 month-old; n = 8 WT (B6J), n = 8 AppNL/NL, n = 7 AppNL-G-F/NL-G-F. 8 month-old; n = 8 WT (B6J), n = 7 AppNL/NL, n = 6 AppNL-G-F/NL-G-F

Back to article page