Fig. 2
From: Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis
Emotional learning and fear memory in AppNL-G-F/NL-G-F and AppNL/NL mice, assessed by the contextual fear conditioning task. Learning and memory of contextual fear were assessed at both 6–9 (a–d) and 15–18 (e–h) months of age. At 6–9 months of age, AppNL-G-F/NL-G-F and AppNL/NL mice exhibited similar levels of shock reactivity, as indicated by velocity, during each presentation of footshock (a). During conditioning, all genotypes exhibited the same levels of freezing response to subsequent presentation of footshock (indicated by black arrows) (b). In the context test, all genotypes exhibited similar increases in the freezing response during the test, as revealed by the min-by-min data (c). Total levels of freezing response during the 5-min test period were comparable among all genotypes (d). At 15–18 months of age, AppNL-G-F/NL-G-F mice exhibited higher shock reactivity than WT mice, as revealed by an increase in velocity during the second and third footshocks (e). During conditioning, all genotypes exhibited the same levels of freezing response to subsequent presentation of footshock (indicated by black arrows) (f). The time course of the freezing response in the context test was not different among genotypes (g). During the 5-min test period, the percentages of time spent in the frozen state by AppNL-G-F/NL-G-F and AppNL/NL mice were similar to that in WT mice (h). 6–9 month-old; n = 6 WT (B6J), n = 6 AppNL/NL, n = 9 AppNL-G-F/NL-G-F. 15–18 month-old; n = 8 WT (B6J), n = 7 AppNL/NL, n = 7 AppNL-G-F/NL-G-F