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Table 1 Contribution in percentage of the whole-cell Ca2+ current for each class of Ca2+ channel

From: Calcium currents in striatal fast-spiking interneurons: dopaminergic modulation of CaV1 channels

Antagonist Nicardipine ω-conotoxin GVIA ω-Agatoxin TK SNX-482 TTA-P2
Concentration 20 µM 1 µM 1 µM 1 µM 1 µM
Ca2+ channel antagonist CaV1 CaV2.2 CaV2.1 CaV2.3 CaV3
% of current blocked (mean ± S.E.M) 38 ± 1.1 23.4 ± 0.7 11.1 ± 1.4 20 ± 2 7.4 ± 2.3
n 12 14 14 6 13
p 0.0001 0.0001 0.0033 0.0009 0.0202
  1. The first row (not counting the title) indicates the Ca2+ channel antagonist used. The second row contains saturating concentrations used. Third row stands for the specific Ca2+ channel class that was blocked. The fourth row displays the mean ± SEM of Ca2+ current blocked in percentage by each antagonist. Antagonists were tested alone or in sequence in different orders. Percentages were obtained from a system of linear equations that used data from all experiments (see Materials and methods). The fifth row shows samples size: the number of neurons tested with each antagonist. The sixth row indicates statistical significance or P-value of percentage blockade by each antagonist as compared to whole-cell current average before adding any antagonist (Kruskal–Wallis ANOVA with post hoc Dunn’s test of each paired comparison against the control: whole-cell Ca2+ current)