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Fig. 5 | BMC Neuroscience

Fig. 5

From: Calcium currents in striatal fast-spiking interneurons: dopaminergic modulation of CaV1 channels

Fig. 5

Excitability increase by SKF in current clamp experiments is occluded by nicardipine. a Top: immunocytochemical preparation showing striatal fluorescent neurons from a PV-cre mouse infected with adeno-associated virus with tdTomato (red). Middle: Corroboration by a fluorescein isothiocyanate (FITC) conjugated antibody against PV (green). Bottom: Merge. b Evoked firing to different stimulus strengths (somatic current injections values at left). Note that bath application of 10 μM SKF increased firing rate and this action is reversed by 20 μM nicardipine, suggesting that increases in firing are due to CaV1 channels. c Summary of changes in a sample of neurons in which mean firing rate at rheobase was compared (n = 6; P < 0.0021; Friedman ANOVA with post hoc Dunn’s test using average firing rate at rheobase). d Bath application of SKF increased mean firing rate an effect which was reversed by 100 nM SCH (n = 4)

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