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Fig. 3 | BMC Neuroscience

Fig. 3

From: Calcium currents in striatal fast-spiking interneurons: dopaminergic modulation of CaV1 channels

Fig. 3

Activation of D1-class DA receptors enhances whole-cell Ca2+ currents in FSI. a Left: Representative time course (left) and representative I–V plots (right) showing that activation of D1-like DA receptors by addition of the selective DA agonist 10 µM SKF-81297 (SKF) to the bath solution enhances control Ca2+ currents. b Box plots summary of absolute Ca2+ current amplitudes in control, during SKF and after washing the agonist (n = 8; Friedman ANOVA test F2,14 = 13, P = 0.0003; *P < 0.05, **P < 0.01; post hoc Dunn’s multiple comparisons test). c Time course of maximum Ca2+ current showing specific blockade of SKF actions by the selective DA receptor antagonist 100 nM SCH-23390 (SCH) in the presence of SKF. Removal of SCH leads to an enhancement of Ca2+ current by SKF. Representative I–V plots at right. d Box plot summarizing the absolute current amplitude in control conditions and during addition of SCH plus SKF (n = 8; P = 0.99; Wilcoxon T test)

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