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Fig. 4 | BMC Neuroscience

Fig. 4

From: Melatonin ameliorates cognitive memory by regulation of cAMP-response element-binding protein expression and the anti-inflammatory response in a rat model of post-traumatic stress disorder

Fig. 4

Effects of MTG on brain-derived neurotrophic factor (BDNF) and cAMP-response element-binding (CREB) protein levels (a and b) and BDNF and CREB mRNA expression in the hippocampus of rats with SPS-induced memory impairments. Polymerase chain reaction (PCR) bands on agarose gels and relative intensities (c). BDNF and CREB mRNA expression was normalized to the expression of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) mRNA as an internal control. Parameters were determined at the end of the experiments. Data are expressed as the mean ± SEM of 4 animals in each group. *p<0.05, **p < 0.01 versus the CON group; #p < 0.05, ##p < 0.01 versus the SPS group

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BMC Neuroscience

ISSN: 1471-2202

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