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Fig. 3 | BMC Neuroscience

Fig. 3

From: Melatonin ameliorates cognitive memory by regulation of cAMP-response element-binding protein expression and the anti-inflammatory response in a rat model of post-traumatic stress disorder

Fig. 3

Effects of MTG on recognition memory assessed by the novel object recognition test (ORT) in which the time spent sniffing familiar and novel objects during a 3-min choice trial (a) and the ability to discriminate (b) between familiar and novel objects were measured. The Morris water maze (MWM) test was used to assess the effects of MTG on spatial learning and memory. Time to escape (latency) from the water onto a submerged platform during acquisition trials (c), percentages of time spent in the target quadrant (d), percentages of distance traversed in the target quadrant (e), and swimming speed (f) were used as outcome measures. The open field test (OFT) was used to assess the effect of MTG on locomotor activity (counts) and total number of rearing bouts (g). Six or seven rats were used per treatment group. Data are represented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 versus the CON group; #p < 0.05, ##p < 0.01, ###p < 0.001 versus the SPS group

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