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Table 1 Effect of zinc and linoleic acid and their combination on LPO and the antioxidant system enzymes in mid brain of rotenone treated rats

From: Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism

Groups

MDA (µmoles/mg protein)

TAC (µmoles/mg protein)

GSH (µmoles/mg protein)

SOD (UI/mg protein)

CAT (µmole H2O2/min/mg protein)

GPx (UI/ml enzymes)

TP (mg protein)

Mean ± SEM

Vehicle (n = 6)

0.03 ± 0.01

699.2 ± 3.473

4.44 ± 0.43

6.68 ± 1

0.64 ± 0.01

0.0200 ± 0.003536

10.67 ± 1.052

Rotenone (n = 5)

0.44 ± 0.06a

554.6 ± 8.921a

0.57 ± 0.18a

1.42 ± 0.63a

0.22 ± 0.03a

0.0062 ± 0.002131

9.370 ± 0.3590

Zinc (n = 6)

0.03 ± 0.01*c

686.7 ± 8.559*

3.91 ± 0.31*

5.16 ± 0.24b

0.74 ± 0.03*,d

0.0358 ± 0.006778b

10.41 ± 0.06512

Linoleic acid (n = 6)

0.02 ± 0.00*c

702.1 ± 4.699*

3.76 ± 0.49*

5.34 ± 1.04b

0.74 ± 0.04*,d

0.0752 ± 0.004758*,c

10.95 ± 0.2067

Zinc + linoleic acid (n = 5)

0.07 ± 0.03*c

630.2 ± 33.28b

3.62 ± 0.34*

7.11 ± 0.73b

0.68 ± 0.05*

0.0812 ± 0.007716*,c

11.30 ± 0.6652

Levodopa (n = 5)

0.43 ± 0.04

692.7 ± 3.239*

3.69 ± 0.23*

5.09 ± 0.55b

0.50 ± 0.08b

0.0170 ± 0.0030

11.28 ± 0.3937

  1. Total protein and antioxidant biomarker activity and concentration in the midbrain of the experimental groups. Results are expressed as mean ± SEM
  2. LPO lipid peroxidation
  3. ap ≤ 0.0001 compared to vehicle group; bp ≤ 0.05 compared to rotenone group; cp ≤ 0.0001 compared to levodopa group, dp ≤ 0.05 compared to levodopa group
  4. *p ≤ 0.0001 compared to rotenone group