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Table 6 Multivariate analysis of factors associated with neurological involvement in primary and secondary Sjögren’s syndrome

From: Clinical features and risk factors of neurological involvement in Sjögren’s syndrome

Independent variables

Multivariate analysis

OR (95% CI) P value

pSS

sSS

Age < 50

Sex (male)

4.56 (1.15, 20.01) 0.013

 

Low C3 level (< 0.9 g/L)

2.21 (1.04, 4.82) 0.026

3.33 (1.92, 8.03) 0.021

Xerophthalmia, n (%)

 

3.03 (1.08, 7.45) 0.030

Age >= 50

ANA positivity

5.52(1.42, 37.28) 0.037

 

Cardiac involvement

2.38 (1.18, 5.06) 0.013

 

Saliva gland atrophy

0.28 (0.13, 0.59) 0.001

 

Xerophthalmia, n (%)

 

4.07 (1.25, 14.35)0.012

  1. NP neurological, ESSDAI European League Against Rheumatism Sjögren’s syndrome disease activity index, ESSPRI European League Against Rheumatism Sjögren’s syndrome patient reported index, ANA antinuclear antibodies, C3 complement component 3, C4 complement component 4, CRP C-reactive protein, ESR erythrocyte sedimentation rate, LSGB labial salivary gland biopsy, RF rheumatoid factor