Table 5 Univariate and multivariate analysis of factors associated with neurological involvement in primary and secondary Sjögren’s syndrome
From: Clinical features and risk factors of neurological involvement in Sjögren’s syndrome
Independent variables | Univariate analysis OR (95% CI) P value | |
|---|---|---|
pSS | sSS | |
Age < 50 | ||
Sex (male) | 4.55 (1.27, 16.29) 0.020 | – |
ESSDAI | 1.47 (1.26, 1.72) < 0.001 | 1.27 (1.05, 1.53) 0.0136 |
Xerophthalmia, n (%) | 3.25 (1.03, 10.23) 0.0440 | |
Low C3 level (< 0.9 g/L) | 2.10 (1.06, 4.13) 0.032 | 3.83 (1.31, 11.24) 0.0143 |
Low C4 level (< 0.1 g/L) | – | 3.50 (1.02, 12.00) 0.0463 |
RF positive, n (%) | – | 0.32 (0.12, 0.87) 0.0251 |
ESR (mm/h) | 0.98 (0.96, 1.00) 0.038 | – |
Age ≥ 50 | ||
Constitutional domain involvement | 1.96 (1.08, 3.55) 0.027 | – |
ESSDAI | 1.52 (1.34, 1.72) < 0.001 | 1.44 (1.16, 1.80) 0.001 |
ANA positivity, n (%) | 4.50 (1.02, 19.83) 0.047 | – |
Cardiac involvement, n (%) | 2.28 (1.21, 4.31) 0.010 | – |
Xerophthalmia, n (%) | 1.82 (1.02, 3.27) 0.044 | 4.82 (1.56, 14.95) 0.006 |
Low C3 level (< 0.9 g/L) | 1.83 (1.01, 3.30) 0.046 | – |
Saliva gland atrophy | 0.38 (0.19, 0.74) 0.004 | – |
ESR (mm/h) | – | 0.98 (0.96, 1.00) 0.0336 |