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Fig. 1 | BMC Neuroscience

Fig. 1

From: Chronic oxycodone induces axonal degeneration in rat brain

Fig. 1

Prolong oxycodone administration affects axonal structures in rat brain. a Immunofluorescent analysis of MBP (red) and NF (green) in corpus callosum (upper images) and in striatum (lower images) of rats treated with water (W) or oxycodone (O). Blue is DAPI staying. Scale bars denote 5 μm for all images. Images represent immunofluorescent analysis of striatum and corpus callosum of three rats for each treatment from the different matching litters. b Immunofluorescent analysis of MBP (red) and NF (green) in axonal fascicles in striatum of rats treated with water (W) or oxycodone (O). Scale bar denotes 50 μm for all images. On right, graphs representing mean size of fascicles stained with MBP or NF antibodies in striatum. Open bars—water samples; grey filled bars—oxycodone samples. Data is expressed in arbitrary units normalized to that in water brain samples set as 1 (± SEM). Three to five brain slides containing whole striatum areas from three water-and three oxycodone-treated rats from the different matching litters were analysed. MBP, p < 0.001; NF, p < 0.001. c Immunofluorescent analysis of MBP (red) and NF (green) in cerebellum of rats treated with water (W) or oxycodone (O). Blue is DAPI staining. Scale bar denotes 50 μm for all images. Images represent immunofluorescent analysis of cerebellum areas of three rats for each treatment from the different matching litters

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