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Fig. 3 | BMC Neuroscience

Fig. 3

From: Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology

Fig. 3

Systematic sampling strategy for the cortical regions of the frontal lobe. The 3-D MRI image on top left-hand corner represents slicing of the brain on coronal plane. Each slice numbered consecutively in rostral-caudal axis and labelled as anterior (a) or posterior (b) when digitally photographed. Images 2b–6b show gross brain coronal slices (posterior plane) with mirrored structural MR image from the left hemisphere. Key neuroanatomical regions middle frontal gyrus (white rectangle), orbitofrontal cortex (orbital gyri and gyrus rectus: turquoise rectangle) and inferior frontal gyrus (orange rectangle) were sampled in serial coronal slices systematically with their accompanying subcortical white matter. Major sulci were used as landmarks for region and anatomical boundary identification. Annotations—1: superior frontal gyrus, 2: middle frontal gyrus, 3: medial orbital gyrus, 4: gyrus rectus, 5: olfactory sulcus, 6: inferior frontal sulcus, 7: inferior frontal gyrus, 8: circular insular sulcus, arrow: superior frontal sulcus. Scale bar = 2 cm

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