Fig. 13

Predicted sensitivity of MRI modalities to microstructural properties of the neural tissue. Structural, diffusion, relaxography and susceptibility MRI (top row) modalities can be influenced by several aspects of tissue microstructure. The bottom row represents microstructural features and an example of their corresponding histological stain. Predicted relationships between MRI and histology are indicated by dashed lines. The black dashed lines indicate microstructural features that can strongly influence MR signal [7, 107, 119,120,121,122,123,124]. The grey dashed lines represent other microstructural features that can potentially influence the MR signal (directly or indirectly) and/or to a lesser degree [98, 121]. It should also be noted that any MR measure might show correlation with other microstructural characteristics that are not highlighted in the image