Fig. 10

Histology and MRI quantitative maps. Colour deconvolution markup histology images stained for PLP (a) and SMI-312 (b) demonstrates negative stained pixels = blue, weak positive pixels = yellow, medium positive pixels = orange and strong positive pixels = red. The PLP markup image shows manual outline of the grey matter and the subcortical white matter (green line). Images on the right column demonstrate quantitative FA (c) and MD (d) maps from the corresponding MRI plane and their calibration bars with quantitative values. Scale bar = 5 mm