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Table 2 Minor allele frequencies of 5 SNPs included in analysis. SNPs are sorted by chromosomal position. SNPs with significant association to AD in bold

From: Haplotype analysis of APOE intragenic SNPs

SNP ID

Alleles (MAF 1st)

Type

Global MAF

1000G (MAF) samples

ADNI (MAF) samples

Afr

Asian

Eur

AD

MCI

CT

rs440446

C/G

Noncoding

0.37

0.130

0.371

0.367

0.279

0.355

0.383

rs769449

A/G

Noncoding

0.06

0.000

0.084

0.121

0.314

0.168

0.098

rs769450

A/G

Noncoding

0.33

0.289

0.192

0.423

0.276

0.347

0.389

rs429358

C/T

Missense

0.15

0.292

0.087

0.141

0.418

0.218

0.139

rs7412

T/C

Missense

0.07

0.084

0.075

0.067

0.022

0.058

0.070

Sample size

   

185

286

365

183

370

256