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Table 1 Biochemical parameters of plasma in Wistar and OXYS rats treated chronically with CEF

From: Modulation of the expression of genes related to the system of amyloid-beta metabolism in the brain as a novel mechanism of ceftriaxone neuroprotective properties

Biochemical parameters Wistar OXYS
Control (saline) CEF (100 mg/kg/day, 36 days) Control (saline) CEF (100 mg/kg/day, 36 days)
Uric acid (mmol/L) 7.48 ± 0.41 7.56 ± 0.26 7.70 ± 0.18 8.19 ± 0.42
Creatinine (µmol/L) 59.21 ± 0.44 57.70 ± 1.04 60.55 ± 0.71 58.74 ± 0.93
ALT, U/L 72.33 ± 4.03 70.56 ± 4.72 79.14 ± 2.58 64.00 ± 1.77$
AST, U/L 132.66 ± 3.34 137.64 ± 6.01 187.13 ± 15.04***,### 148.72 ± 4.51$$
Total bilirubin (µmol/L) 2.38 ± 0.21 1.99 ± 0.31 2.10 ± 0.21 1.79 ± 0.24
Ca2+ (mmol/L) 2.78 ± 0.03 2.70 ± 0.04 2.68 ± 0.03 2.59 ± 0.06**
Phosphate (mmol/L) 2.49 ± 0.06 2.46 ± 0.10 2.58 ± 0.17 2.30 ± 0.06
Total cholesterol (mmol/L) 1.82 ± 0.06 1.74 ± 0.14 1.42 ± 0.14*,# 1.56 ± 0.05
Triglycerides, g/L 1.07 ± 0.17 1.14 ± 0.12 1.30 ± 0.10 1.59 ± 0.15*,#
LDL-C (µmol/L) 0.463 ± 0.075 0.495 ± 0.089 0.213 ± 0.079*,# 0.200 ± 0.031*,##
HDL (mmol/L) 0.869 ± 0.042 0.843 ± 0.066 0.704 ± 0.060* 0.774 ± 0.045
  1. Data are presented as the Mean ± S.E.M. of the values obtained in an independent group of animals (n = 7–8 per group)
  2. Statistically significant differences: *P < 0.05, ***P < 0.001 versus “Wistar + saline” group; #P < 0.05, ##P < 0.01, ###P < 0.001 versus “Wistar + CEF” group; $P < 0.05, $$P < 0.01 versus “OXYS + saline” group
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BMC Neuroscience

ISSN: 1471-2202

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