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Table 1 Biochemical parameters of plasma in Wistar and OXYS rats treated chronically with CEF

From: Modulation of the expression of genes related to the system of amyloid-beta metabolism in the brain as a novel mechanism of ceftriaxone neuroprotective properties

Biochemical parameters

Wistar

OXYS

Control (saline)

CEF (100 mg/kg/day, 36 days)

Control (saline)

CEF (100 mg/kg/day, 36 days)

Uric acid (mmol/L)

7.48 ± 0.41

7.56 ± 0.26

7.70 ± 0.18

8.19 ± 0.42

Creatinine (µmol/L)

59.21 ± 0.44

57.70 ± 1.04

60.55 ± 0.71

58.74 ± 0.93

ALT, U/L

72.33 ± 4.03

70.56 ± 4.72

79.14 ± 2.58

64.00 ± 1.77$

AST, U/L

132.66 ± 3.34

137.64 ± 6.01

187.13 ± 15.04***,###

148.72 ± 4.51$$

Total bilirubin (µmol/L)

2.38 ± 0.21

1.99 ± 0.31

2.10 ± 0.21

1.79 ± 0.24

Ca2+ (mmol/L)

2.78 ± 0.03

2.70 ± 0.04

2.68 ± 0.03

2.59 ± 0.06**

Phosphate (mmol/L)

2.49 ± 0.06

2.46 ± 0.10

2.58 ± 0.17

2.30 ± 0.06

Total cholesterol (mmol/L)

1.82 ± 0.06

1.74 ± 0.14

1.42 ± 0.14*,#

1.56 ± 0.05

Triglycerides, g/L

1.07 ± 0.17

1.14 ± 0.12

1.30 ± 0.10

1.59 ± 0.15*,#

LDL-C (µmol/L)

0.463 ± 0.075

0.495 ± 0.089

0.213 ± 0.079*,#

0.200 ± 0.031*,##

HDL (mmol/L)

0.869 ± 0.042

0.843 ± 0.066

0.704 ± 0.060*

0.774 ± 0.045

  1. Data are presented as the Mean ± S.E.M. of the values obtained in an independent group of animals (n = 7–8 per group)
  2. Statistically significant differences: *P < 0.05, ***P < 0.001 versus “Wistar + saline” group; #P < 0.05, ##P < 0.01, ###P < 0.001 versus “Wistar + CEF” group; $P < 0.05, $$P < 0.01 versus “OXYS + saline” group