Fig. 4From: RETRACTED ARTICLE: Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s diseaseCur and SLCP treatments partially protect neuronal morphology in the 5xFAD mice brain tissue. The 5xFAD mice were treated with Cur or SLCP for 2- or 5-days, sacrificed, and the subsequent cryostat sections were stained with 0.1% cresyl violet, from which images were taken using Olympus microscope (total magnification: 1000x) in the PFC and the CA1 and CA3 regions of hippocampus. a Pyknotic, tangle-like, neurons along with vacuoles were observed in 5xFAD tissue with Cur- or SLCP-treatment reducing this abnormal morphology in the PFC and hippocampal neurons following 5-, but not 2-days of treatment. b The number of pyknotic cells were less after 5 days of treatment (*p < 0.05; **p < 0.01) in all three areas, when compared to the 5xFAD mice receiving only vehicle or the 5xFAD mice receiving only 2 days treatment. Scale bar indicates 25 µm and is applicable to other images. Arrows indicate pyknotic or tangle-like neuronsBack to article page