Fig. 13

Cur and SLCP reduce neuroinflammation in entorhinal cortex in 5xFAD mice. The 5xFAD mice were treated with Cur or SLCP for 2- or 5-days, sacrificed, and their brain sections were collected and immunolabeled for Iba-1 and GFAP. The number of labeled Iba-1-IR (a, b) and GFAP-IR (a, c) cells was significantly reduced (**p < 0.01) in the entorhinal cortex in comparison to vehicle-treated 5xFAD mice. Significant reduction in both GFAP-IR and Iba-1-IR was observed after 5 days, in comparison to those receiving 2 days, of treatment (b, c). Scale bar indicates 250 µm and is applicable to other images