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Fig. 13 | BMC Neuroscience

Fig. 13

From: Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease

Fig. 13

Cur and SLCP reduce neuroinflammation in entorhinal cortex in 5xFAD mice. The 5xFAD mice were treated with Cur or SLCP for 2- or 5-days, sacrificed, and their brain sections were collected and immunolabeled for Iba-1 and GFAP. The number of labeled Iba-1-IR (a, b) and GFAP-IR (a, c) cells was significantly reduced (**p < 0.01) in the entorhinal cortex in comparison to vehicle-treated 5xFAD mice. Significant reduction in both GFAP-IR and Iba-1-IR was observed after 5 days, in comparison to those receiving 2 days, of treatment (b, c). Scale bar indicates 250 µm and is applicable to other images

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