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Fig. 12 | BMC Neuroscience

Fig. 12

From: Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease

Fig. 12

Cur and SLCP treatments reduce neuroinflammation in subicular complex of hippocampus in 5xFAD mice. The 5xFAD mice were treated with Cur or SLCP for 2- or 5-days, sacrificed, and their brain sections were collected and immunolabeled for Iba-1 and GFAP. The number of Iba-1-IR (a, b) and GFAP-IR (a, c) cells were significantly reduced (*p < 0.05; **p < 0.01) in subicular complex of hippocampus of Cur- or SLCP-treated, versus vehicle-treated 5xFAD mice. Further reduction was observed after 5 days of treatment in comparison to 2 days, of treatment for both GFAP and Iba-1 labeling in both the Cur- and SLCP-treated 5xFAD mice (b, c). Scale bar indicates 250 µm and is applicable to other images

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