Fig. 12

Cur and SLCP treatments reduce neuroinflammation in subicular complex of hippocampus in 5xFAD mice. The 5xFAD mice were treated with Cur or SLCP for 2- or 5-days, sacrificed, and their brain sections were collected and immunolabeled for Iba-1 and GFAP. The number of Iba-1-IR (a, b) and GFAP-IR (a, c) cells were significantly reduced (*p < 0.05; **p < 0.01) in subicular complex of hippocampus of Cur- or SLCP-treated, versus vehicle-treated 5xFAD mice. Further reduction was observed after 5 days of treatment in comparison to 2 days, of treatment for both GFAP and Iba-1 labeling in both the Cur- and SLCP-treated 5xFAD mice (b, c). Scale bar indicates 250 µm and is applicable to other images