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Fig. 10 | BMC Neuroscience

Fig. 10

From: Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease

Fig. 10

Cur and SLCP treatments reduce neuroinflammation in CA3 region of hippocampus in 5xFAD mice. The 5xFAD mice were treated with Cur or SLCP for 2- and 5-days, sacrificed, and their brain sections were collected and immunolabeled for Iba-1 and GFAP. The number of Iba-1-IR (a, b) and GFAP-IR (a, c) labeled cells were significantly reduced (*p < 0.05; **p < 0.01) in the CA3 region of hippocampus in comparison to untreated 5xFAD mice. Further reduction was observed after 5 days, in comparison to 2 days, of treatment in the amount of labeling for both GFAP and Iba-1 (b, c). Scale bar indicates 250 µm and is applicable to other images

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