Fig. 10

Cur and SLCP treatments reduce neuroinflammation in CA3 region of hippocampus in 5xFAD mice. The 5xFAD mice were treated with Cur or SLCP for 2- and 5-days, sacrificed, and their brain sections were collected and immunolabeled for Iba-1 and GFAP. The number of Iba-1-IR (a, b) and GFAP-IR (a, c) labeled cells were significantly reduced (*p < 0.05; **p < 0.01) in the CA3 region of hippocampus in comparison to untreated 5xFAD mice. Further reduction was observed after 5 days, in comparison to 2 days, of treatment in the amount of labeling for both GFAP and Iba-1 (b, c). Scale bar indicates 250 µm and is applicable to other images