Skip to main content
Fig. 3 | BMC Neuroscience

Fig. 3

From: Intraventricular infusion of clusterin ameliorated cognition and pathology in Tg6799 model of Alzheimer’s disease

Fig. 3

Soluble Aβ decreased and LRP-2 increased after intraventricular (icv)-delivering clusterin peptide D-[113–122]. Quantification of the soluble Aβ levels in hippocampus and the surrounding temporal cortex by ELISA revealed decreased soluble Aβ40 level (a) and soluble Aβ42 level (b). Western-Blot of protein lysates from hippocampus and the surrounding temporal cortex revealed increased LRP-2 expression in clusterin treated mice in comparison to non-treat and NS group (c). Density of LRP-2 was displayed in ratio to no-treat group (%) (d). 8 months of age, n = 9–10 per group. Data are presented as mean ± S.E.M. *p < 0.05; one-way ANOVA followed by Turkey post hoc test

Back to article page
\