Fig. 2

Decreased amyloid plaque and CAA following 2 weeks intraventricular (icv) treatment of clusterin peptide D-[113–122] in comparison to saline (NS) or nothing (non-treat). Images show amyloid plaque burden in hippocampus of Tg6799 mouse after icv-treatment of nothing (A, D), saline (NS, B, E) and clusterin peptide D-[113–122] (C, F) as well as the CAA burden in cortical region of Tg6799 mouse after icv-treatment of nothing (G), saline (NS, H) and clusterin peptide D-[113–122] (I). Quantitative analysis of the percentage hippocampal area (J) occupied by amyloid plaque (Aβ42 immunohistochemistry study) and percentage cortical area (K) occupied by CAA (Aβ40 immunohistochemistry study) demonstrated a decrease after icv infusion of clusterin in Tg6799 mouse. Analysis involved 10 serial sections per mouse for cortex and 5 serial sections for hippocampus. 8 months of age, n = 5 per group. Data are presented as mean ± S.E.M. Scale bar = 100um. *p < 0.05; one-way ANOVA followed by Turkey post hoc test