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Table 1 Effects of azine derivatives on NO production in LPS-activated BV-2 cells

From: N,N-disubstituted azines attenuate LPS-mediated neuroinflammation in microglia and neuronal apoptosis via inhibiting MAPK signaling pathways

Compound

IC a50 (µM)

Cell viabilityb(%)

Compound 1

58.52

90.33 ± 9.37

Compound 2

50.12

96.58 ± 1.75

Compound 3

12.47

100.73 ± 2.53

Compound 4

> 500

91.03 ± 3.39

Compound 5

59.91

97.55 ± 10.59

Compound 6

47.36

87.90 ± 19.53

Compound 7

39.94

77.24 ± 5.67

Compound 8

47.89

69.45 ± 3.25

Compound 9

26.27

83.54 ± 7.78

L-NMMAc

18.32

100.40 ± 3.41

  1. aThe IC50 value of each compound was defined as the concentration (in µM) that caused 50% inhibition of NO production in LPS-activated BV-2 cells
  2. bThe cell viability was measured at 20 µM of compound treatment and it was expressed as a percentage (%) of the LPS-only treatment group. The results are the average of three independent experiments and the data are expressed as mean ± standard deviation
  3. cL-NMMA was used as a positive control