Compound | IC
a50
(µM) | Cell viabilityb(%) |
---|
Compound 1 | 58.52 | 90.33 ± 9.37 |
Compound 2 | 50.12 | 96.58 ± 1.75 |
Compound 3
|
12.47
|
100.73 ± 2.53
|
Compound 4 | > 500 | 91.03 ± 3.39 |
Compound 5 | 59.91 | 97.55 ± 10.59 |
Compound 6 | 47.36 | 87.90 ± 19.53 |
Compound 7 | 39.94 | 77.24 ± 5.67 |
Compound 8 | 47.89 | 69.45 ± 3.25 |
Compound 9 | 26.27 | 83.54 ± 7.78 |
L-NMMAc
| 18.32 | 100.40 ± 3.41 |
-
aThe IC50 value of each compound was defined as the concentration (in µM) that caused 50% inhibition of NO production in LPS-activated BV-2 cells
-
bThe cell viability was measured at 20 µM of compound treatment and it was expressed as a percentage (%) of the LPS-only treatment group. The results are the average of three independent experiments and the data are expressed as mean ± standard deviation
-
cL-NMMA was used as a positive control