Fig. 8
From: Downstream mediators of Ten-m3 signalling in the developing visual pathway
Schematic diagram illustrating potential interactions and changes in Ten-m3 KOs. a In WT mice, Ten-m3 acts to repress Zic2, a promoter of EphB1 transcription. Ten-m3 also promotes EphA7 expression. These interactions may be direct or indirect. Other interactions are also possible. For example, Ten-m3’s regulation of EphA7 may involve or be downstream of its interaction with Zic2 (not shown). b In Ten-m3 KO mice the repression of Zic2 is removed and thus Zic2 is upregulated which in turn drives increased expression of EphB1. The positive regulation of EphA7 by Ten-m3 is also removed causing a reduced expression of EphA7 compared to WT