Fig. 2

Segregation of ipsilateral and contralateral retinal axons proceeds in Ten-m3 KOs despite ipsilateral mismapping. Conventions are the same as for Fig. 1 but for P6–7 and P9–10 mice as marked. A, B In P6–7 WTs (A), contralateral label showed a clear reduction in a patch within the dorsomedial part of the dLGN. Ipsilateral label was confined to this region (A′, A″). In Ten-m3 KOs (B) the ipsilateral label formed a condensed band that stretched along much of the DM-VL extent of the nucleus (B′, B″). The contralateral label showed a complementary pattern (B). C, D By P9–10, projections look largely adult-like in WT mice, with a condensed ipsilateral zone situated dorsomedially (C′, C″), and contralateral terminations filling the rest of the nucleus (C). In Ten-m3 KO mice (D) the mature pattern was also apparent. The ipsilateral projection persists as a condensed band of terminals which extends into the ventrolateral dLGN (D′, D″) and contralateral terminals avoiding this region (D). Dorsal (D) is to the top and lateral (L) to the right of each image, as marked in A″. Scale bars: 200 μm