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Table 1 Dock score of the top nine interacting drugs with multiple target proteins

From: In silico repurposing of antipsychotic drugs for Alzheimer’s disease

Name of the ligand Docking score
  AChE (4EY6) BuChE (1P0M) MAO A (2Z5X) BACE 1 (3L5E) BACE 1 (4D8C) NMDA (1PBQ)
Positive control Donepezil
− 11.02
Rivastigmine
− 3.123
Marplan
− 8.354
LY2886721
− 6.123
LY2886721
− 6.80
Memantine
− 4.029
Sulmepride − 11.508 − 7.246 − 3.649 − 4.831
Promazine hydrochloride − 11.074 − 7.978 − 5.907 − 6.784 − 4.711
Bromperidol − 10.927 − 8.111 − 5.52 − 6.576 − 7.486 − 5.247
Anisopirol − 11.001 − 7.977 − 5.26 − 6.083 − 8.169 − 6.903
Melperone − 11.423 − 6.663 − 8.91 − 7.249 − 6.524 − 6.067
Pimozide − 14.969 − 8.13 − 8.386 − 8.968 − 6.854
Benperidol − 14.425 − 7.163 − 6.598 − 6.742 − 9.076 − 6.778
Azabuperone − 11.882 − 7.938 − 5.861 − 7.584 − 4.167 − 6.51
Anisoperidone − 7.989 − 6.324 − 8.513 − 7.11 − 5.196