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Table 1 Comparison of software packages that measure intracellular calcium activity

From: PeakCaller: an automated graphical interface for the quantification of intracellular calcium obtained by high-content screening

Software package Major features of calcium dynamics References
SIMA Amplitude
Time of onset
Area under the curve
Frequency
Activation and decay time
[19, 20]
FluoroSNNAP Amplitude
Functional connectivity
Synchronization analysis
Correlation coefficient
Frequency
Activation and decay time
Wavelet-based detection
[15]
NeuroCa Amplitude
Frequency
Background correction
Analysis of ~ 1000 cells
Network dynamics
[17]
PeakCaller Frequency
Synchronization index
Correlation coefficient
Event rise and fall time
 
MATLAB dynamics Amplitude
Frequency
Time of onset after stimulus
Area under the curve
Response duration
Full width half max
Decay time constant
[16]
MATLAB script Amplitude
Frequency
Automated detection of single cells in dense cultures
Background correction
[18]