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Fig. 5 | BMC Neuroscience

Fig. 5

From: A convenient UHPLC-MS/MS method for routine monitoring of plasma and brain levels of nicotine and cotinine as a tool to validate newly developed preclinical smoking model in mouse

Fig. 5

Plasma and brain levels of nicotine and cotinine in mouse. Nicotine and cotinine concentrations in mouse plasma and brain one and 2 weeks post exposure to TS (a). Plasma versus brain level and plasma : brain ratio of nicotine and cotinine 2 weeks post exposure to TS. **** p < 0.0001 plasma concentration of analytes against corresponding brain level, plasma:brain ratio of nicotine against plasma:brain ratio of cotinine (b)

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