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Fig. 6 | BMC Neuroscience

Fig. 6

From: Musashi-1 is the candidate of the regulator of hair cell progenitors during inner ear regeneration

Fig. 6

Ototoxic damage induced DNA synthesis and the expression of MSI1, HES5, and CNND1 in the vestibular sensory epithelium. Seven-day-old chickens received daily intramuscular injections of gentamicin sulfate (300 mg/kg) for 4 consecutive days, and utricles were then analyzed for BrdU incorporation and gene expression. a BrdU labeling in the sensory epithelium after aminoglycoside treatment. b Relative mRNA expression of MSI1, HES5, and CNND1 on days 2, 7, and 14 after the last aminoglycoside injection. mRNA levels in the treated chickens were normalized to those in untreated 12-day-old chickens as a control; *p < 0.05. c Western blotting analysis showing that MSI1 and CNND1 proteins were upregulated in the sensory epithelium during cell proliferation in the damaged inner ear. RE, relative expression normalized to the control sample

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