Target gene | Substrate | Differentiation media | Differentiation media | Differentiation media | Â |
---|---|---|---|---|---|
Day 1 (10e−5) | Day 3 (10e−5) | Day 5 (10e−5) | Day 1–5 pattern | ||
Dystrobrevin-Alpha | PDL | 139 ± 10 | 340 ± 15 | 703 ± 19 | Increase |
 | Lm-2 | 93 ± 6 | 305 ± 08 | 826 ± 54 | Increase |
Dystrobrevin-Beta | PDL | 54 ± 3 | 31 ± 2 | 32 ± 1 | No change |
 | Lm-2 | 58 ± 7 | 22 ± 2 | 22 ± 2 | No change |
Dystroglycan | PDL | 3235 ± 217 | 3387 ± 168 | 5543 ± 245 | No change |
 | Lm-2 | 3096 ± 406 | 3225 ± 455 | 3814 ± 225 | No change |
Dystrophin | PDL | 205 ± 0.5 | 360 ± 19 | 562 ± 34 | No change |
 | Lm-2 | 216 ± 20 | 240 ± 4 | 410 ± 47 | No change |
Dystrophin related protein 2 (DRP2) | PDL | 106 ± 6 | 85 ± 5 | 110 ± 10 | No change |
 | Lm-2 | 140 ± 7 | 51 ± 2 | 49 ± 4*** | Decrease |
Sarcoglycan-Alpha | PDL | 218 ± 27 | 328 ± 21 | 585 ± 13 | Increase |
 | Lm-2 | 178 ± 2 | 243 ± 35 | 359 ± 18*** | No change |
Sarcoglycan-Beta | PDL | 1976 ± 70 | 2091 ± 75 | 3215 ± 49 | Increase |
 | Lm-2 | 1776 ± 151 | 1614 ± 134 | 2048 ± 61*** | No change |
Sarcoglycan-Delta | PDL | 53 ± 3 | 26 ± 0.4 | 27 ± 0.5 | Decrease |
 | Lm-2 | 41 ± 2 | 24 ± 0.6 | 32 ± 2 | No change |
Sarcoglycan-Epsilon | PDL | 175 ± 6 | 10 ± 2 | 139 ± 0.9 | No change |
 | Lm-2 | 150 ± 6 | 99 ± 1 | 156 ± 6 | No change |
Sarcoglycan-Gamma | PDL | 27 ± 4 | 42 ± 4 | 73 ± 3 | Increase |
 | Lm-2 | 25 ± 0.5 | 19 ± 1 | 41 ± 1*** | No change |
Sarcoglycan-Zeta | PDL | 57 ± 4 | 43 ± 4 | 38 ± 3 | No change |
 | Lm-2 | 64 ± 6 | 28 ± 0.4 | 22 ± 2 | No change |
Syntrophin-Alpha1 | PDL | 44 ± 3 | 64 ± 3 | 100 ± 4 | No change (p = 0.079) |
 | Lm-2 | 33 ± 5 | 48 ± 1 | 123 ± 9 | Increase |
Syntrophin-Beta1 | PDL | 251 ± 14 | 111 ± 6 | 132 ± 7 | Decrease |
 | Lm-2 | 252 ± 9 | 121 ± 10 | 128 ± 9 | Decrease |
Syntrophin-Beta2 | PDL | 48 ± 6 | 41 ± 1 | 63 ± 5 | No change |
 | Lm-2 | 16 ± 0.6 | 9 ± 0.3 | 10 ± 0.1 | No change |
Syntrophin-Gamma1 | PDL | 232 ± 21 | 106 ± 3 | 159 ± 5 | No change |
 | Lm-2 | 115 ± 6 | 108 ± 4 | 141 ± 6 | No change |
Syntrophin-Gamma2 | PDL | 43 ± 2 | 18 ± 0.6 | 24 ± 2 | No change |
 | Lm-2 | 24 ± 3 | 16 ± 0.6 | 28 ± 0.9 | No change |
Utrophin | PDL | 16 ± 0.4 | 12 ± 0.1 | 15 ± 0.8 | No change |
 | Lm-2 | 16 ± 0.6 | 9 ± 0.3 | 10 ± 0.1 | Decrease |