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Table 2 mRNA levels of DGC components in differentiating oligodendrocytes (relative to GAPDH, n = 3)

From: Myelination is delayed during postnatal brain development in the mdx mouse model of Duchenne muscular dystrophy

Target gene

Substrate

Differentiation media

Differentiation media

Differentiation media

 

Day 1 (10e−5)

Day 3 (10e−5)

Day 5 (10e−5)

Day 1–5 pattern

Dystrobrevin-Alpha

PDL

139 ± 10

340 ± 15

703 ± 19

Increase

 

Lm-2

93 ± 6

305 ± 08

826 ± 54

Increase

Dystrobrevin-Beta

PDL

54 ± 3

31 ± 2

32 ± 1

No change

 

Lm-2

58 ± 7

22 ± 2

22 ± 2

No change

Dystroglycan

PDL

3235 ± 217

3387 ± 168

5543 ± 245

No change

 

Lm-2

3096 ± 406

3225 ± 455

3814 ± 225

No change

Dystrophin

PDL

205 ± 0.5

360 ± 19

562 ± 34

No change

 

Lm-2

216 ± 20

240 ± 4

410 ± 47

No change

Dystrophin related protein 2 (DRP2)

PDL

106 ± 6

85 ± 5

110 ± 10

No change

 

Lm-2

140 ± 7

51 ± 2

49 ± 4***

Decrease

Sarcoglycan-Alpha

PDL

218 ± 27

328 ± 21

585 ± 13

Increase

 

Lm-2

178 ± 2

243 ± 35

359 ± 18***

No change

Sarcoglycan-Beta

PDL

1976 ± 70

2091 ± 75

3215 ± 49

Increase

 

Lm-2

1776 ± 151

1614 ± 134

2048 ± 61***

No change

Sarcoglycan-Delta

PDL

53 ± 3

26 ± 0.4

27 ± 0.5

Decrease

 

Lm-2

41 ± 2

24 ± 0.6

32 ± 2

No change

Sarcoglycan-Epsilon

PDL

175 ± 6

10 ± 2

139 ± 0.9

No change

 

Lm-2

150 ± 6

99 ± 1

156 ± 6

No change

Sarcoglycan-Gamma

PDL

27 ± 4

42 ± 4

73 ± 3

Increase

 

Lm-2

25 ± 0.5

19 ± 1

41 ± 1***

No change

Sarcoglycan-Zeta

PDL

57 ± 4

43 ± 4

38 ± 3

No change

 

Lm-2

64 ± 6

28 ± 0.4

22 ± 2

No change

Syntrophin-Alpha1

PDL

44 ± 3

64 ± 3

100 ± 4

No change (p = 0.079)

 

Lm-2

33 ± 5

48 ± 1

123 ± 9

Increase

Syntrophin-Beta1

PDL

251 ± 14

111 ± 6

132 ± 7

Decrease

 

Lm-2

252 ± 9

121 ± 10

128 ± 9

Decrease

Syntrophin-Beta2

PDL

48 ± 6

41 ± 1

63 ± 5

No change

 

Lm-2

16 ± 0.6

9 ± 0.3

10 ± 0.1

No change

Syntrophin-Gamma1

PDL

232 ± 21

106 ± 3

159 ± 5

No change

 

Lm-2

115 ± 6

108 ± 4

141 ± 6

No change

Syntrophin-Gamma2

PDL

43 ± 2

18 ± 0.6

24 ± 2

No change

 

Lm-2

24 ± 3

16 ± 0.6

28 ± 0.9

No change

Utrophin

PDL

16 ± 0.4

12 ± 0.1

15 ± 0.8

No change

 

Lm-2

16 ± 0.6

9 ± 0.3

10 ± 0.1

Decrease

  1. *** Significant differences in DGC component mRNA levels when comparing cells grown on PDL to those on Laminin