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Table 2 Summary of outcomes following partial transection injury and treatment with combinations of ion channel inhibitors to inhibit VGCCs, Ca2+ permeable AMPARs and/or P2X7Rs at 3 days after injury

From: Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

Ion channels inhibited Vehicle VGCC VGCC + Ca2+ permeable AMPAR VGCC + P2X7R VGCC + P2X7R + Ca2+ permeable AMPAR
Outcome measure  
 Visual function ~ ~ ~ ~
 Tau[pS396]/total Tau
 Tau[pT205]/total Tau
 Acetylated tubulin
 NogoA
 MBP ~ ~
 Paranodal gap length
 Paranode length ~
 Ankyrin G length ~ ~
 Microglia/macrophages ~ ~ ~ ~
 Acrolein ~ ~ ~ ~
 HNE ~ ~ ~ ~
 OPCs ~ ~ ~
 8OHDG ~
 CML ~ ~ ~ ~
 3NT ~ ~ ~
 MnSOD ~ ~
  1. Symbols for vehicle treated animals indicate direction of change from normal untreated animals. Following treatment with ion channel inhibitors, significant decreases relative to injured animals treated with vehicle are shown as ↓, significant increases as ↑, remaining significant differences to normal are indicated by—(p ≤ 0.05) and intermediate outcomes not significantly different from vehicle treated or normal as ~(p > 0.05)