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Table 1 Summary of studies and experimental paradigms

From: Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents

Study

Species

Sex

Age (weeks)

Dosing Regimen

Brain Regions

Figure(s)

References

Network analysis

Mouse

Female

48

Chronic

Hippocampus

Figures 2, 3, 4, 5 and Additional file 1: Table S1

Li et al. [20]

Network analysis

Rat

Male

8

Acute

Frontal cortex

Figures 2, 3, 4, 5 and Additional file 1: Table S2

du Jardin et al. [24]

OpenArray qPCR

Rat

Male

12

Chronic

Frontal cortex, Hippocampus

Figure 6

Waller-et al. [27]

  1. Outline of experimental conditions for mouse and rat studies used in the network analysis and for the OpenArray qPCR study for biological validation of the network analysis. See references for additional details regarding these studies including animal models and differentiation to other antidepressants