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Fig. 6 | BMC Neuroscience

Fig. 6

From: Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents

Fig. 6

Vortioxetine significantly regulates biomarkers within the protein–protein interactome identified by the network analysis. qPCR analysis following chronic vortioxetine (VOR) administration at a range of doses reveals genes identified in the network analysis are significantly modulated by vortioxetine. a Plasticity-related targets. Arc is significantly downregulated in response to 0.6 and 1.8 g/kg VOR in the frontal cortex and in response to 1.8 g/kg VOR in the hippocampus. Cortex: *p = 0.021, 0.6 g/kg versus control (Ctrl); **p = 0.005, 1.8 g/kg versus Ctrl. Hippocampus: *p = 0.033, 1.8 g/kg versus Ctrl. b Transcription factors. Fos is significantly downregulated in response to 0.6 and 1.8 g/kg VOR in the frontal cortex and hippocampus. Cortex: *p = 0.034, 0.6 g/kg versus Ctrl; **p = 0.007, 1.8 g/kg versus Ctrl. Hippocampus: **p = 0.009, 0.6 g/kg versus Ctrl; **p = 0.004, 1.8 g/kg versus Ctrl. c Endocytosis/actin remodeling and neurodevelopment/plasticity. Epn1 is significantly upregulated in response to 0.22 and 0.6 g/kg VOR treatment in the frontal cortex. *p = 0.070, 0.22 g/kg versus Ctrl; **p = 0.001, 0.6 g/kg versus Ctrl. Sema4g is significantly upregulated following 0.22 g/kg vortioxetine treatment in the frontal cortex. *p = 0.040, 0.22 g/kg versus Ctrl. All values are represented as fold change relative to the control group and denoted as mean ± SEM. Statistical significance is defined as a FDR p value of p < 0.05. n = 12 animals per group

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