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Fig. 5 | BMC Neuroscience

Fig. 5

From: Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents

Fig. 5

Protein complex analysis. a Complex 1544—the Arc pathway, synaptic plasticity-related, is regulated by vortioxetine treatment at the mRNA level. b Complex 85—transcriptional regulation, including FOS modulated by vortioxetine at the mRNA level. c Complex 163—endocytosis/neurotransmitter release pathways, including EPN1 that was upregulated in the qPCR study. d DLG4/PSD-95 network, including SEMA4G that was upregulated in the qPCR study. The connecting lines represent physical protein–protein interactions. The targets outlined in red indicate genes modulated in response to chronic vortioxetine treatment in adult rats. The scale indicates p values for significance of differential expression, ranging from green (p = 0) to dark red (p = 1). Targets with colored borders represent the rat p value, and center colors indicate mouse p values. Gray represents targets in which no qPCR data were obtained

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