Fig. 4

Merged mouse and rat network (mapped to human proteins) and overlapping Reactome pathways. Genes are colored according to their Reactome pathway memberships (DLG4 is part of both ‘Interactions of neurexins and neuroligins at synapses’ and ‘Activation of Ca²⁺-permeable Kainate receptors’ pathways). The most prevalent Reactome pathways are shown. The network includes 13 (equal to 22%) of the proteins from the ‘Interactions of neurexins and neuroligins at synapses’ pathway, 6 (equal to 60%) of the proteins from the ‘Activation of Ca²⁺-permeable Kainate receptors’ pathway, 8 (equal to 50%) of the proteins from the ‘mTOR signaling’ pathway, and 7 (equal to 7%) of the proteins from the ‘Cargo recognition for clathrin-mediated endocytosis’ pathway. Reactome pathway annotations were filtered to include only reviewed human proteins from UniProt and protein-pathway associations with the evidence code “traceable author statement” (TAS)