Fig. 2
From: Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents
Mouse and rat networks mapped to human proteins. a Mouse network. The 5 significantly-regulated targets following correction for multiple testing were used to generate a protein–protein interaction network. The genes highlighted in green represent the 5 differentially-regulated mouse genes. p = 0.001652, Wilcoxon, enrichment of significantly-regulated biomarkers relative to vehicle-treated mice. b Rat network. The 14 differentially-regulated genes before correction for multiple testing were used for the network analysis. The genes highlighted in green represent the 14 targets that showed significance following differential analysis. p = 0.00000642, Wilcoxon, enrichment of significantly-regulated targets in comparison to vehicle-treated rats. The scale indicates p values for significance of differential expression, ranging from green (p = 0) to dark red (p = 1)