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Table 1 Overview of the experimental design of the two parallel sub-studies

From: Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides

Study Observation time (days) Experimental groups n Group name Performed experiments
Study I (ULUND) 56 Healthy rats: Hollow chitosan nerve guide 5 hCNG-Ihealthy Analysis of regenerative matrix and distal nerve segment: Presence of axons and activated and apoptotic Schwann cells by immunohistology; Analysis of sensory dorsal root ganglion activation and neuroprotection by immunohistology
Diabetic GK rats: Hollow chitosan nerve guide 11 hCNG-Idiabetic
Healthy rats: Chitosan film enhanced chitosan nerve guide 6 CFeCNG-Ihealthy
Diabetic GK rats: Chitosan film enhanced chitosan nerve guide 7 CFeCNG-Idiabetic
Study II (MHH) 150 Hollow chitosan nerve guide 10 hCNG-II Motor recovery: Non-invasive electrophysiology (60, 90, 120, 150 days) and muscle weight ratio; Histomorphometry; Immunohistology
Chitosan film enhanced chitosan nerve guide 7 CFeCNG-II
  1. GK Goto-Kakizaki rats, hCNG hollow chitosan nerve guides, CFeCNG chitosan film enhanced chitosan nerve guides, I short-term experiments, II long-term experiments, ULUND University of Lund, MHH Medizinische Hochschule Hannover, i.e. Hannover Medical School