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Fig. 6 | BMC Neuroscience

Fig. 6

From: Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides

Fig. 6

Immunohistology of cross-sections through distal parts of regenerated tissue within the nerve guides. At 150 days after delayed nerve reconstruction, immunohistological analysis of cross-sections through distal parts of the regenerated tissue within the nerve guides was performed. A, B Representative photomicrographs displaying the immunodetection of all regenerated axons (NF200 in green), regenerated motor axons (ChAT in red; co-localization with NF200 is indicated in yellow) and nuclear staining in blue (DAPI). Arrows in (B) indicate the location of the central chitosan film and a tissue bridge that has formed through one of the holes in it connecting the two strands of the regenerate. C Quantification of axonal profiles revealed a tendency to increased numbers of motor axons in the CFeCNG-II group. D The percentage of ChAT-immunopositive motor axons is significantly increased in CFeCNG-II samples (*p < 0.05). Error bars indicate mean ± SEM

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BMC Neuroscience

ISSN: 1471-2202

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