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Fig. 2 | BMC Neuroscience

Fig. 2

From: Investigating the impact of electrical stimulation temporal distribution on cortical network responses

Fig. 2

Analysis of evoked activity for the two designed protocols. a PSTH map of sample experiment during irregular (β = 1, black trace) and regular (β = ∞, gray trace) stimulation, delivered from channel 55, marked with an ‘X’ on the map. a1 and a2 show respectively the PSTH profiles observed during the first (STIM1) and second (STIM2) repetition of the same stimulation protocol. Scale bars for a1 and a2. X axis Time [0–400 ms]; Y axis Spike Count [0–2]. b Computation of the average number of evoked spikes during the two stimulation sessions of protocol 1. b1 and b2 show the mean number of evoked spikes computed for all the performed experiments, respectively, during first and second repetition, i.e. STIM1 and STIM2, with varying values of β used during the stimulation session (i.e. β = 0, β = 0.5, β = 1, β = 1.5, β = ∞). No statistical difference is observed among the five conditions (p > 0.05, One-way ANOVA, post hoc Bonferroni’s method). c Computation of the average number of evoked spikes during the two stimulation sessions of protocol 2. c1 and c2 show, respectively, the mean number of evoked spikes computed for all the performed experiments during first and second repetitions of protocol 2, with varying values of β (i.e. β = 1, black bars; β = ∞, light gray bars) and mean stimulation rates (MSR): fMBR/2 (0.07 ± 0.04, mean ± SD), fMBR (0.14 ± 0.08 Hz, mean ± SD), fMFR (0.54 ± 0.34 Hz, mean ± SD), respectively equal to half MBR, MBR and MFR obtained with an on-the-fly analysis of the first hour of the network’s spontaneous activity. A significant statistical difference was observed for β = ∞ between the number of evoked spikes obtained during regular stimulation at fMBR/2 and fMFR (*p < 0.05, One-way ANOVA, post hoc Bonferroni’s method) for both repetitions. Data used to compute the statistical distributions reported in (b) and (c) are included in Additional file 2

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