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Fig. 5 | BMC Neuroscience

Fig. 5

From: Using Kalirin conditional knockout mice to distinguish its role in dopamine receptor mediated behaviors

Fig. 5

KalSRDrd2-KO mice exhibited an ifenprodil-sensitive decrease in anxiety-like behavior in the elevated zero maze. a Male and female control (KalSRCKO) and KalSRDAT-KO mice were tested in the elevated zero maze; open area time did not differ between controls and KalSRDAT-KO mice (with no differences between male and females, data were grouped; N = 49 KalSRCKO; N = 54 KalSRDAT-KO). b Male and female control (KalSRCKO) and KalSRDrd1a-KO mice were tested in the elevated zero maze; open area time did not differ between controls and KalSRDrd1a-KO (with no sex differences, data were grouped; N = 7 KalSRCKO control; N = 12 KalSRDrd1a-KO). c Both male and female Kal7Drd2-KO mice exhibited significantly reduced anxiety-like behavior (p < 0.005) compared to control mice (Kal7CKO) (N = 29 Kal7CKO, N = 20 Kal7Drd2-KO males; N = 18 Kal7CKO, N = 11 Kal7Drd2-KO females). d Control (Kal7CKO) and Kal7Drd2-KO mice were given a 2 mg/kg injection (i.p.) of ifenprodil 10 min before testing for 5 min in the elevated zero maze. Since there was no sex difference (c), data for males and females were pooled. Ifenprodil pretreatment abrogated the genotypic difference (N = 11 each, Kal7CKO and Kal7Drd2-KO; pooled data from (a) were repeated for comparison). e Model of dendritic spines in Drd2-expressing neurons of WT and Kal7KO mice and elevated zero maze response (EZM) before and after blockade of GluN2B-containing GluN receptors by low dose ifenprodil. Model incorporates the decrease in GluN2B seen after Kal7 knockout [9] and the direct interaction of the PH domain of Kal7 with the cytoplasmic tail of GluN2B [28]

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