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Fig.Ā 3 | BMC Neuroscience

Fig.Ā 3

From: Antagonistic action on NMDA/GluN2B mediated currents of two peptides that were conantokin-G structure-based designed

Fig.Ā 3

EAR16 but not EAR18 shows selectivity for GluN2B over GluN2A. a, b EAR16-mediated inhibition of NMDA-evoked inward currents on HEK-293 cells expressing GluN1Aā€“GluN2B subunits (a) or expressing GluN1Aā€“GluN2A subunits (b). d, e EAR18-mediated inhibition of NMDA-evoked inward currents on HEK-293 cells expressing GluN1Aā€“GluN2B (d) or in cells GluN1Aā€“GluN2A subunits (e). c, f The areas of the NMDA-evoked inward currents were normalized to that measured prior to the addition of EAR16 (c) or EAR18 (f) (āˆ’1: maximal inward current; 0: no current). No significant difference was found between ā€œcontrol-NMDAā€ and ā€œwash-NMDAā€. Significant different compared to ā€œcontrol-NMDAā€ (left symbol) or when compared to ā€œwash-NMDAā€ (right symbol) #pĀ <Ā 0.0001, +pĀ <Ā 0.001, @pĀ <Ā 0.02, two-way ANOVA with Sidakā€™s multiple comparison post-test; n (number of cells) EAR16, nĀ =Ā 4 for GluN1Aā€“GluN2B, and nĀ =Ā 4 for GluN1Aā€“GluN2A; EAR18 nĀ =Ā 3 for GluN1ā€“GluN2B (washout nĀ =Ā 2) and nĀ =Ā 4 for GluN1Aā€“GluN2A

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