Fig. 4

Steroid receptor agonist induced transcriptome alterations. Microarray results are shown as a heat map and include the top 100 genes with significant differences shown by two-way ANOVA for the drug factor. Colored rectangles represent transcript abundance in neurons and astrocytes in control samples (CTRL) and after treatment with dexamethasone (DEX), aldosterone (ALD), progesterone (PG), dihydrotestosterone (DHT) or estradiol (ES). The intensity of the color is proportional to the standardized values (blue low, red high). Clustering was performed using correlation distance and complete tree-building method. Particularly interesting gene symbols are shown on the right. The data for neurons and astrocytes were adjusted for means in the control groups to better visualise the effects of steroid compounds. FPKM—fragments per kilobase of exon per million fragments mapped