Fig. 7

Social avoidance of adult male mice in the open field test. The test mouse was exposed to the open field for 20 min. A social (male mouse) target was present at the center of the inside arena. Time in the inside zone (a) and time spent immobile in the inside zone (b) were observed in wild-type (blue), CD157 KO mice (gray), and CD157 KO mice given an intraperitoneal injection of 100 ng/ml × 0.3 ml of OT (orange) are shown. Data are means  ±  S.D., n  =  8. Two-way ANOVA revealed significant treatment (PBS vs. OT) x genotype (wild-type vs. KO) interaction effects in a (F _2,42 = 6.041, P = 0.0005) and b (F _2.42 = 5.674, P = 0.0066). Values in CD157 ^−/− mice treated with OT are significantly higher than those in CD157 ^−/− mice with no treatment or those treated with PBS at P  <  0.001 in (a) and (b). *P < 0.001 compared OT treatment with no treatment or treated with PBS in CD157 ^−/− mice (Tukey’s post hoc test)